影响力医生

姓      名  : 付振明

性      别  :

专      业  : 肿瘤

职      称  : 主任医师

医      院  : 武汉大学人民医院

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详细信息: 专业技术 1. 临床技术:熟练掌握当前肿瘤放化疗先进技术,从2004年起开始开展调强放疗(IMRT)、图像引导放疗(IGRT)、自适应放疗(ART),体部立体定向放疗(SBRT)及各种肿瘤分子靶向、个体化的肿瘤综合治疗方案。 熟练掌握Tomotherapy. 2. 基础及转化研究技术: 1). 率先在国际上提出以肿瘤流行病学为桥梁来进行肿瘤转化研究策略。是国际上少数几个开发并掌握转化医学研究策略的专家。为此被美国国立癌症研究所,以“特殊才能外国人才引进”(H1b visa)。 2). 在国际首先提出的新孟德尔随机化分析概念,为此获邀于2012年四月在芝加哥召开的AACR年会上大会发言 (invited oral presentation) 宣讲(http://cancerres.aacrjournals.org/cgi/content/short/72/8_MeetingAbstracts/4817?rss=1)。美国国立癌症研究所通报上专题报道,并誉为基因和环境因素的交互作用的新兴方法之一(http://www.cancer.gov/ncicancerbulletin/103012/page6)在肿瘤个体化治疗中也有广阔的前景。回国后主攻方向是基因环境交互作用在肿瘤个体化防治中的转化研究,以及基因和放疗的交互作用应用于放疗新技术的危险评估以及放射剂量学研究。正是目前NIH所倡导的转化及精准医学的范畴。 3. 教学能力: 英语教学主讲教师(本科生,硕/博士研究生课程),国际留学生肿瘤学英语教学主讲教师,英语放射肿瘤专科医师培训计划主讲教师。 已发表的论著论文: 1. Li Q, Zou J, Zhang R, Jia M, Li P, Han J, Huang K, Qiao Y, Xu T, Ruan P, Hu Q, Song Q, Fu ZM*(通讯作者)Palliative gastrectomy and survival in patients with metastatic gastric cancer: a propensity score matched analysis of a large population-based study. Clinical and Translational Gastroenterology. 2019, doi: 10.14309/ctg.0000000000000048. (中科院SCI 2区IF=4.621) 2. 李琴, 付振明*(通讯作者).非小细胞肺癌新辅助化疗的现状分析[J] 国际肿瘤学杂志, 2019,V46(2): 109-112. (中文核心期刊) 3. Fu Z(第一作者), Zhang R, Li P, Jia M. Translational epidemiology: The powerful tool for precision cancer medicine. J Cancer Res Ther. 2019;15(2):269-271. (中科院SCI 4区IF=0.842) 4. Zhang R, Jia M, Li P, Han J, Huang K, Li Q, Qiao Y, Xu T, Ruan P, Hu Q, Song Q, Fu ZM*(通讯作者) Radiotherapy improves the survival of patients with metastatic esophageal squamous cell carcinoma: a propensity score matched analysis of Surveillance, Epidemiology, and End Results database. Dis Esophagus. 2019;32(1). (中科院SCI 3区IF=2.702) 备注:国际食管癌主流专业杂志 5. Zhang R, Li P, Li Q, Qiao Y, Xu T, Ruan P, Song Q, Fu ZM*(通讯作者) Radiotherapy improves the survival of patients with stage IV NSCLC: A propensity score matched analysis of the SEER database. Cancer Med. 2018, 7(10):5015-5026. (中科院SCI 3区 IF=3.202) 6. Zhang R, Li P, Li Q, Qiao Y, Xu T, Ruan P, Song Q, Fu ZM*(通讯作者). Radiotherapy improves the survival of patients with extensive-disease small-cell lung cancer: a propensity score matched analysis of Surveillance, Epidemiology, and End Results database. Cancer Manag Res. 2018, Nov 29;10:6525-6535. (中科院SCI 2区 IF=3.702) 7. Li P, Zhang R, Nie Z, Long M, Zhang G, Fu ZM*(通讯作者) Comparison of Nedaplatin- and Cisplatin-Based Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer Patients: A Propensity Score Analysis. Int J Gynecol Cancer. 2018, 28(5):1029-1037.(中科院SCI 3区 IF=2.369)备注:国际妇科癌主流专业杂志 8. Huang K, Jia M, Li P, Han J, Zhang R, Li Q, Qiao Y, Xu T, Ruan P, Song Q, Fu ZM*(通讯作者) Radiotherapy Improves the Survival of Patients With Metastatic Cervical Cancer: A Propensity-Matched Analysis of SEER Database. Int J Gynecol Cancer. 2018, 28(7):1360-1368. (中科院SCI 3区 IF=2.369)备注:国际妇科癌主流专业杂志 9. 张芮, 宋启斌,付振明*(通讯作者) 武汉大学医学院学生双语教学的调查报告. 中国高等医学教育, 2018(07): 第63-64页.(全国医学教育核心期刊) 10. 乔云锋,李萍,付振明*(通讯作者).顺铂和奈达铂的临床应用[J] 国际肿瘤学杂志, 2018,V45(9): 561-565. (中文核心期刊) 11. Long M, Fu ZM*(通讯作者), Lie Z, Li P. Cigarette Smoking and the Risk of Nasopharyngeal Carcinoma: A Meta-Analysis of Epidemiological Studies. BMJ Open 2017 Oct 5;7(10):e016582. (中科院SCI 3区 IF=2.413) 12. 聂志华,龙梦娟,付振明*(通讯作者) 环境因素影响肿瘤靶向治疗的研究进展[J] 肿瘤代谢与营养电子杂志,2016年 第4期 265-269页 13. Fu ZM et al, INSCOC Group.Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients. J Nutr Oncol 1(1): 52-58, 2016 14. Yu H, Wu Q, Fu Z#, He Y, Liao Z, Xie C, Zhou Y, Zhong Y. A new approach to delineating lymph node target volumes for post-operative radiotherapy in gastric cancer: A phase II trial. Radiother Oncol. 2015 Aug;116(2):245-51. doi: 10.1016/j.radonc.2015.07.010. Epub 2015 Jul 27.(中科院SCI 2区 IF=4.328,肿瘤放疗顶级杂志) 15. Guan GG, Wang WB, Lei BX, Wang QL, Wu L, Fu ZM#, Zhou FX, Zhou YF. UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer. Oncol Lett. 2015 Apr;9(4):1567-1574. Epub 2015 Feb 3. (中科院SCI 4区 IF=1.664) 16. Zheng W, McLerran DF, Rolland BA, Fu Z, Boffetta P, et al. Burden of Total and Cause-Specific Mortality Related to Tobacco Smoking among Adults Aged ≥45 Years in Asia: A Pooled Analysis of 21 Cohorts. PLoS Med. 2014 Apr 22;11(4):e1001631. doi: 10.1371/journal.pmed.1001631(中科院SCI 1区 IF=11.675) 17. Fu Z, Shrubsole MJ, Smalley WE, Zheng W, et al. Associations between dietary fiber and colorectal polyp risk differ by polyp type and smoking status. J Nutr 144: 1–7, 2014(中科院SCI 2区 IF=4.145) 18. Fu Z. Next Generation Epidemiology: The Bridge for Translational Cancer Research and Personalized Medicine. J Cancer Biol Res 2013.1: 2. (Invited editorial) 19. Edwards TL, Shrubsole MJ, Cai Q, Li G, Dai Q, Rex DK, Ulbright TM, Fu Z, Delahanty RH, Murff HJ et al: Genome-Wide Association Study Identifies Possible Genetic Risk Factors for Colorectal Adenomas. Cancer Epidemiol Biomarkers Prev 2013. 22(7):1219-1226. (中科院SCI 2区 IF=4.142) 20. Fu Z, Shrubsole MJ, Li GL, Smalley WE, Hein DW, Cai QY, Ness RM, Zheng W. Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps. Carcinogenesis, 2013 Apr; 34(4):779-86. (中科院SCI 2区 IF=5.072) 21. Fu Z, Shrubsole MJ, Li GL, Smalley WE, Hein DW, Chen Z, Yu S, Cai QY, Ness RM, Zheng W. Using gene-environment interaction analyses to clarifying the association of colorectal polyp risk with well-done meat and heterocyclic amine exposure. Am J Clin Nutr, 2012 Nov;96(5):1119-28. PMID: 23015320(中科院SCI 1区 IF=6.926) 22. Fu Z, Shrubsole MJ, Smalley WE, Wu H, Chen Z, Shyr Y, Ness RM, Zheng W. Lifestyle factors and their combined impact on the risk of colorectal polyps. Am J Epidemiol, 2012 Nov 1;176(9):766-76. PMID: 23079606 (中科院SCI 2区 IF=4.322) 23. Edwards T, Shrubsole MJ, Cai Q, Li G , Dai Q, Rex DK, Ulbright TM, Fu Z, Murff HJ, Smalley WE, Ness RM, Zheng W. A study of prostaglandin pathway genes and interactions with current non-steroidal anti-inflammatory drug use in colorectal adenoma. Cancer Prev Res (Phila). 2012 Jun;5(6):855-63. Epub 2012 May 2. PMID: 22551900. (中科院SCI 2区 IF=3.985) 24. Fu Z, Shrubsole MJ, Smalley WE, Wu H, Chen Z, Yu S, et al. Association of meat intake and meat-derived mutagen exposure with the risk of colorectal polyps by histologic type. Cancer Prev Res 2011 Oct;4(10):1686-97. PMID: 21803984. (中科院SCI 2区 IF=3.985) 25. Fu Z, Deming SL, Fair AM, Shrubsole MJ, Wujcik DM, Shu XO, Kelley M, Zheng W. High intake of meat and meat-derived mutagens increases breast cancer risk: the Nashville Breast Health Study (NBHS) (Breast Cancer Res Tr 2011; 129:919–928, PMID: 21537933(中科院SCI 2区 IF=6.345) 26. Xu H, Fu Z, et al. Extracting and Integrating Data from Entire Electronic Health Records for Detecting Colorectal Cancer Cases (AMIA Annu Symp Proc 2011;1564-72. Epub 2011 Oct 22) PMID: 22195222. 27. Qiu H, Yu IT, Tse SL, Wang XR, Fu ZM. Interaction between continuous variables in logistic regression model. Zhonghua Liu Xing Bing Xue Za Zhi (Chin J Epidemiol). 2010 Jul;31(7):812-814. PMID: 21162850. (In Chinese) 28. Wang XR, Fu ZM et al. Previous Pulmonary Disease and Family Cancer History Increase the Risk of Lung Cancer among Hong Kong Women Cancer Cause Contr. 2009 Jul; 20(5):757-63. PMID: 19169896(中科院SCI 3区 IF=2.510) 29. Qiu H, Yu IT, Wang XR, Fu ZM, Tse SL. Study on the interaction under logistic regression modeling. Zhonghua Liu Xing Bing Xue Za Zhi (Chin J Epidemiol). 2008 Sep;29(9):934-7. PMID: 14521760 (In Chinese) 30. Tse LA, Li ZM, Wong TW, Fu ZM, Yu IT. High prevalence of accelerated silicosis among gold miners in Jiangxi, China. Am J Ind Med. 2007 Dec; 50(12):876-80. PMID: 17948247(中科院SCI 4区 IF=1.729) 31. Tse LA, Fu ZM. A prospective case-control study of ankle fracture in postmenopausal women. Hong Kong Med J. 2006 Aug; 12(4):327. PMID: 16912365. 主持课题: 作为负责人/主持人(PI)承担的美国国立癌症研究所NIH课题 (intramural, 共129.0万美元): 1. Association of lifestyle factors with the receipt of radiation and other treatments for prostate cancer: the NIH-AARP Cohort Study Proposal Id: 201303-0031 Primary Investigator: Zhenming Fu NIH/NCI intramural project(2013.1.1-2015.12.31, 主持人,美国国家级课题). 2. Secondary analysis of existing data for gene-radiation interaction and breast cancer risk in the US radiologic technologist (USRT) cohort study Proposal Id: approved, Id not assigned yet Primary Investigator: Zhenming Fu NIH/NCI intramural project (2013.1.1-2015.12.31主持人,美国国家级课题). 回国后主持课题: 1.代谢酶基因与红肉的交互作用与三阴性乳腺癌发病关联的分子流行病学研究(主持人) 项目来源: 中央高校基本科研业务费专项资金 (拔尖创新人才资助项目 2042014kf0223) 期限 2014.1.1至2015.12.31 金额 20.0万元 2. 红肉与其代谢酶基因的交互作用影响三阴性乳腺癌发病风险的新孟德尔随机化研究(主持人)项目来源: 国家自然科学基金面上项目 (81472971) 期限 2015.1.1至2018.12.31 金额70.0万元 3. 吸烟及其烟雾致癌物与相关代谢酶基因的交互作用影响结直肠癌发病风险的新孟德尔随机化研究(主持人)项目来源: 国家自然科学基金面上项目 (81773555)期限 2018.1.1至2021.12.31 金额45.0万元 主要获奖: 2001.8-2003.12 香港赛马会奖学金 2005.8-2009.8 香港赛马会奖学金 2012 美国癌症研究会 (AACR)表现突出会员 重要大会发言和应邀讲座: 1. 已应邀的讲座 (2018年第六届国际妇产科学术大会(ICGP-2018),2018年6月15日,福冈日本):Comparison of Nedaplatin- and Cisplatin-Based Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer Patients: A Propensity Score Analysis. July 30-August 1, 2018, Fukuoka, Japan. 2. 已应邀讲座(2018年欧洲肺癌大会(ELCC)专题讲座, 2018年4月12日下午,日内瓦,瑞士):Radiotherapy improves the survival of patients with StageIV non-small cell lung cancer: a propensity matched analysis of Surveillance, Epidemiology, and End Results database. 11-14 April, in Geneva, Switzerland. 3. 大会发言(应邀专题发言, 美国癌症研究会年会,2012年4月3日, 芝加哥): Using Mendelian randomization approach to clarifying the association of colorectal polyp risk with well-done meat and heterocyclic amine exposure. Presented to the American Association for Cancer Research annual meeting. AACR Mini-symposium Session: Molecular and Environmental Mechanisms of Carcinogenesis, April 3, 2012, Chicago, USA. 4. 应邀讲座(美国国立癌症研究所专题讲座, 2012年6月28日): Red Meat Intake, Meat-derived Heterocyclic Amine Exposure and Colorectal Polyp Risk: the Tennessee Colorectal Polyp Study. Presented to Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS. June 28, 2012 Rockville, MD,USA 发表摘要: 1 Fu ZM, Yeo W, Wong WL, Lai BS , Johnson P J , Zhong S. Mitochondrial Poly-C Tract Mutations in Hepatocellular Carcinoma (HCC) of Chinese Patients, Proceedings of 94th Proceedings of 102th the American Association for Cancer Research (AACR) annual meeting, 2003. Mar,(44):269-270.Washington D.C. 2 Fu ZM, Deming SL, Fair AM, Shrubsole MJ, Wujcik DM, Shu XO, Kelley M, Zheng W. Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: The Nashville Breast Health Study. Proceedings of 102th the American Association for Cancer Research annual meeting, 2011 35: abstract # 3718 3 Fu ZM, Shrubsole MJ, Li GL, Smalley WE, Hein DW, Chen Z, Yu S, Cai QY, Ness RM, Zheng W. Using mendelian randomization approach to clarifying the association of colorectal polyp risk with well-done meat and heterocyclic amine exposure. Cancer Res 2012 72 (8 Supplement) 72(8), S1:4817-4817. 4 Fu ZM, Shrubsole MJ and Zheng W. Dietary fiber intake reduces colorectal polyp risk in cigarette smokers. Abstract submitted to AACR 2013 annual meeting (13-A-6477-AACR) 专业杂志特邀编委 (Editorial board): Cancer Biology & Research (Editorial board) JSM Translational Medicine & Epidemiology (Editorial board) 专业杂志特邀审稿: PloS Medicine American Journal of Epidemiology Carcinogenesis Journal of Clinical Endocrinology Metabolism China Medical Journal (English)中华医学杂志英文版 专业学术任职情况: 国际: 美国临床肿瘤学会 (ASCO ) 会员 美国癌症研究会 (AACR) 会员 世界华人肿瘤医师协会华人放射治疗协作组(CRTOG)国际交流工作委员会副主委 世界华人肿瘤医师协会华人放射治疗协作组(CRTOG)执行委员会委员 国内: 湖北省抗癌协会肿瘤放疗专业委员会 副主任委员 湖北省中医药专业委员会 副主任委员 中国抗癌协会肿瘤营养治疗专委会 副 秘书长 中国临床肿瘤学会放射肿瘤学专业委员会 委员 中部肿瘤放疗联盟(CC-RTOG) 副秘书长 湖北省抗癌协会放射肿瘤学专业委员会 副主任委员 湖北省中西医结合学会肿瘤学专业委员会 副主任委员 国际肿瘤学杂志 通信编委 中国国家卫计委”十三--五”规划教材《肿瘤学概论》英文版 编委 中国抗癌协会肿瘤营养与支持治疗专委会青委会 副主任委员 中国抗癌协会肿瘤营养与支持治疗专业委员会精准肿瘤营养学组 副组长 中国师协会立体定向放疗专业委员会青委会 副主任委员 中国师协会立体定向放疗专业委员会 常务委员 中国医疗保健国际促进会放射肿瘤学专业委员会 委员 中国医师协会结直肠肿瘤专业委员会 委员 中国临床肿瘤学会临床数据专业委员会 委员 湖北省消化肿瘤专业委员会 副主任委员 湖北省临床肿瘤学会胃癌专业委员会 副主任委员 湖北省临床肿瘤学会放射肿瘤学专业委员会 秘书长 湖北省临床肿瘤学会肺癌专业委员会 秘书长 武汉市放射治疗质控中心专家组 副组长 其他: 美国执业医师考试USMLE STEP1, 2:92, 86 中国执业医师

医师特长: 熟练掌握当前肿瘤放化疗先进技术,从2004年起开始开展调强放疗(IMRT)、图像引导放疗(IGRT)、自适应放疗(ART),体部立体定向放疗(SBRT)及各种肿瘤分子靶向、个体化的肿瘤综合治疗方案。

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